Accessed 5 Oct 2020
Schell TD, Mylin LM, Georgoff I, Teresky AK, Levine AJ, Tevethia SS
Phase II Detoxification : This tripeptide serves as a cofactor for glutathione S-transferases, conjugating with xenobiotics and metabolic waste products to facilitate their elimination through bile and urine pathways
Moreover, glutamine is an important source of amide nitrogen for nucleotide synthesis, and it contributes to the activation of the mTORC1 pathway which promotes mTORC1-dependant metabolic reprogramming, increasing the proliferation and growth of tumors [36-40]
This causes the rate of the GS reaction to come back down to normal despite the upregulation of CBS and GCS and cause the steady concentrations of cytosolic GSH and the blood concentrations of GSH and cysteine to decline below normal
This behavioral disadvantage, however, was significantly reduced in the ICV-STZ rats on berberine supplementation, indicating that berberine was able to preserve memory and learning in rats that would have otherwise been subjected to the neurocognitive deficits associated with Alzheimers disease
